Researchers at NORUT Biotech in Tromsø, Norway have developed a new set of heterobifunctional self-eliminating linkers for use in ADC conjugation, amongst other applications.
Our technology combines known cysteine-based conjugation chemistry with novel and an innovative self-releasing cyclisation technology, that provides an ADC that leaves the unmodified drug at the target site. Linker release is initiated by a validated disulfide bond cleavage mechanism, which can be modulated for stability.
A subsequent intramolecular reaction by the linker yields an unmodified cytotoxin. Carbonate or carbamate linkage options provide new possibilities to adjust ADC stability and utilize both hydroxyl- and amine-containing payloads
We foresee a number of ways our linker can be used in the ADC industry
Our linkers have been sythesised and we have several samples available for testing. The linker technology is protected under patent pending.